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Journal Article 15

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cardiac hypertrophy 2

3D parametric model 1

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Cardiac arrhythmia 1

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Cardiac pathology diagnosis 1

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Data augmentation 1

Diabetic cardiomyopathy 1

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GSK-3β 1

Heart regeneration 1

Heparanase 1

Lipoprotein lipase 1

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Domain knowledge enhanced deep learning for electrocardiogram arrhythmia classification Research Article

Jie SUN,sunjie@nbut.edu.cn

Frontiers of Information Technology & Electronic Engineering 2023, Volume 24, Issue 1, Pages 59-72 doi: 10.1631/FITEE.2100519

Abstract: Deep learning provides an effective way for automatic classification of s, but in , pure data-driven methods working as black-boxes may lead to unsatisfactory results. A promising solution is combining with deep learning. This paper develops a flexible and extensible framework for integrating with a deep neural network. The model consists of a deep neural network to capture the statistical pattern between input data and the ground-truth label, and a knowledge module to guarantee consistency with the . These two components are trained interactively to bring the best of both worlds. The experiments show that the is valuable in refining the neural network prediction and thus improves accuracy.

Keywords： Domain knowledge Cardiac arrhythmia Electrocardiogram (ECG) Clinical decision-making

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Integrated management of cardiac failure: the cardiac failure clinic

Daniel LOISANCE

Frontiers of Medicine 2011, Volume 5, Issue 1, Pages 20-25 doi: 10.1007/s11684-011-0106-1

Abstract:

The prevalence of the risk factors and the risk of cardiac failure are both increasing in China.The wide range of clinical presentations of cardiac failure (acute or chronic) and of therapeutic approachesintegration within the same structure of the various experts involved in the diagnosis and the treatment of cardiacIn these centers, collaboration should replace competition between the medical and the surgical cardiac

Keywords： cardiac failure cardiac transplantation mechanical circulatory support

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Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in

Frontiers of Medicine Pages 939-956 doi: 10.1007/s11684-023-0987-9

Abstract: To this end, 12 645 cardiac cells were generated from embryonic day 17.5 and postnatal days 2 and 8 miceThree cardiac developmental paths were identified: two switching to cardiomyocytes (CM) maturation withThese findings could improve the understanding of MNDCM heterogeneity and cardiac development, thus providingnew clues for approaches to effective cardiac regeneration.

Keywords： mononuclear diploid cardiomyocytes cell–cell communication cardiac fibroblast single-cell RNA sequencing cardiac regeneration

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Association of cardiac disease with the risk of post-lung transplantation mortality in Chinese recipients

Frontiers of Medicine 2023, Volume 17, Issue 1, Pages 58-67 doi: 10.1007/s11684-022-0937-y

Abstract: Kaplan–Meier estimates showed that recipients with cardiac abnormalities had a significantly increasedAfter adjusting for potential confounders, cardiac abnormality was shown to be independently associated

Keywords： cardiac disease mortality aged population lung transplantation

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Management of mantle cell leukemia with cardiac involvement leading to cardiogenic shock

Muhammad Furqan,Yamei Chen,Akintunde Akinleye,Judy Sarungbam,Alan Gass,Karen Seiter,Delong Liu

Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 254-258 doi: 10.1007/s11684-014-0319-1

Abstract: Here we report a case of cardiac involvement by mantle cell leukemia leading to cardiogenic shock which

Keywords： mantle cell lymphoma bendamustine cardiogenic shock

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Effects of RNA interference targeting angiotensin 1a receptor on blood pressure and cardiac hypertrophy

ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen

Frontiers of Medicine 2008, Volume 2, Issue 1, Pages 19-24 doi: 10.1007/s11684-008-0005-2

Abstract: the effects of RNA interference (RNAi) targeting angiotensin 1a receptor (AT1a) on blood pressure and cardiactargeting AT1a receptor inhibits the development of renovascular hypertension and the accompanying cardiac

Keywords： therapy Sprague administration cardiac hypertrophy valsartan

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Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis

Wei Gong,Mengwen Yan,Junxiong Chen,Sandip Chaugai,Chen Chen,Daowen Wang

Frontiers of Medicine 2014, Volume 8, Issue 4, Pages 445-455 doi: 10.1007/s11684-014-0378-3

Abstract: The purpose of this study was to investigate the effects of PDE5 inhibitor on cardiac fibrosis.In control mice, 4 weeks of TAC induced significant cardiac dysfunction, cardiac fibrosis, and cardiacSildenafil treatment markedly prevented TAC-induced cardiac dysfunction, cardiac fibrosis and cardiacIn isolated cardiac fibroblasts, sildenafil blocked TGF-β1-induced cardiac fibroblast transformationthrough CREB activation in cardiac fibroblasts.

Keywords： PDE5 cardiac fibrosis TGF-β CREB

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Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling

Samuel Chege Gitau,Xuelian Li,Dandan Zhao,Zhenfeng Guo,Haihai Liang,Ming Qian,Lifang Lv,Tianshi Li,Bozhi Xu,Zhiguo Wang,Yong Zhang,Chaoqian Xu,Yanjie Lu,Zhiming Du,Hongli Shan,Baofeng Yang

Frontiers of Medicine 2015, Volume 9, Issue 4, Pages 444-456 doi: 10.1007/s11684-015-0421-z

Abstract: Changes in the cardiac structure and function were assessed through echocardiography and transmission

Keywords： aspirin Akt cardiac hypertrophy GSK-3β Wnt/β-catenin

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PAK1 is a novel cardiac protective signaling molecule

Yunbo Ke,Xin Wang,Xu Yu Jin,R. John Solaro,Ming Lei

Frontiers of Medicine 2014, Volume 8, Issue 4, Pages 399-403 doi: 10.1007/s11684-014-0380-9

Abstract:

We review here the novel cardiac protective effects of the multifunctional enzyme, p21-activated kinasereview, we assemble an overview of the recent findings on PAK1 signaling in the heart, particularly its cardiacWe present a model for PAK1 signaling that provides a mechanism for specifically affecting cardiac cellularWe discuss the anti-adrenergic and antihypertrophic cardiac protective effects of PAK1, as well as its

Keywords： p21-activated kinase 1 (PAK1) heart

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Right coronary occlusion following transcatheter aortic valve implantation: two case reports

Gang Zhang,Jun Luo,Guo Chen

Frontiers of Medicine 2016, Volume 10, Issue 3, Pages 351-355 doi: 10.1007/s11684-016-0465-8

Abstract:

This paper discusses two male patients with severe aortic stenosis, whose right coronary arteries (RCA) were completely occluded during transcatheter aortic valve implantation (TAVI), leading to fatal hemodynamic disorder. Occlusions of RCA complicated by TAVI are rare. In addition, emergency cardiopulmonary bypass (CPB) played a critical role in rescuing our second patient. Both patients were admitted for “severe aortic stenosis,” and TAVIs were performed. The first patient’s blood pressure immediately dropped to 70/40 mmHg after the balloon expansion and did not increase much after the administration of aramine or fluid therapy. He did not receive emergency surgery and died after 1.5 h of resuscitation. The second patient’s blood pressure fluctuated greatly for several minutes after the valve implantation, ranging from 170/100 mmHg to 60/40 mmHg. Angiography revealed a total occlusion of RCA. Thoracic surgery with CPB was performed, and the patient survived.

Keywords： aortic stenosis transcatheter aortic valve implantation right coronary occlusion cardiac group

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Cardiac Remote Conditioning and Clinical Relevance: All Together Now! Review

Kristin Luther,Yang Song,Yang Wang,Xiaoping Ren,W. Keith Jones

Engineering 2015, Volume 1, Issue 4, Pages 490-499 doi: 10.15302/J-ENG-2015117

Abstract: cardioprotective “conditioning” phenomena represent activation from different entry points of a cardiacand nociceptive stimuli is emerging as a potential non-ischemic and non-traumatic means to initiate cardiac

Keywords： remote cardioprotection cardiac conditioning non-ischemic conditioning peripheral nociceptive stimulus

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Familial amyloid cardiomyopathy masquerading as chronic Guillain-Barre syndrome: things are not always what they seem

Die Hu, Ling Liu, Shuguang Yuan, Yuhong Yi, Daoquan Peng

Frontiers of Medicine 2017, Volume 11, Issue 2, Pages 293-296 doi: 10.1007/s11684-017-0516-9

Abstract: diseases, particularly in patients with pronounced neurological presentations and unexplained or equivocal cardiacanalysis, explained the concurrence of independent pathological features, including neuropathy and cardiac

Keywords： transthyretin (TTR) cardiac amyloidosis sick sinus syndrome chronic Guillain-Barre syndrome

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Application of Biomaterials in Cardiac Repair and Regeneration Review

Zhi Cui,Baofeng Yang,Ren-Ke Li

Engineering 2016, Volume 2, Issue 1, Pages 141-148 doi: 10.1016/J.ENG.2016.01.028

Abstract: Biomaterials, both natural and synthetic, exhibit great potential in cardiac repair and regeneration,

Keywords： Myocardial infarction Heart regeneration Biomaterial Tissue engineering Stem cell

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Visual recognition of cardiac pathology based on 3D parametric model reconstruction Research Article

Jinxiao XIAO, Yansong LI, Yun TIAN, Dongrong XU, Penghui LI, Shifeng ZHAO, Yunhe PAN

Frontiers of Information Technology & Electronic Engineering 2022, Volume 23, Issue 9, Pages 1324-1337 doi: 10.1631/FITEE.2200102

Abstract: Visual recognition of cardiac images is important for and treatment.A new method for classification of cardiac pathology is therefore proposed based on reconstruction.First, 3D heart models are reconstructed based on multiple 3D volumes of cardiac imaging data at theFinally, shape and motion features of 3D heart models across two phases are extracted to classify cardiacComprehensive experiments on the automated cardiac diagnosis challenge (ACDC) dataset of the Statistical

Keywords： 3D visual knowledge 3D parametric model Cardiac pathology diagnosis Data augmentation

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Changes in Lipoprotein Lipase in the Heart Following Diabetes Onset Review

Chae Syng Lee, Yajie Zhai, Brian Rodrigues

Engineering 2023, Volume 20, Issue 1, Pages 19-25 doi: 10.1016/j.eng.2022.06.013

Abstract:

Due to its constant pumping and contraction, the heart requires a substantial amount of energy, with fatty acids (FAs) providing a major part of its adenosine triphosphate (ATP). However, the heart is incapable of making this substrate and attains its FAs from multiple sources, including the action of lipoprotein lipase (LPL). LPL is produced in cardiomyocytes and subsequently secreted to its heparan sulfate proteoglycan (HSPG) binding sites on the plasma membrane. To then move LPL to the endothelial cell (EC) lumen, glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1) attaches to interstitial LPL and transfers it to the vascular lumen, where the LPL is ready to perform its function of breaking down circulating triglycerides (TG) into FAs. The endo-β-glucuronidase heparanase (Hpa) is unique in that it is the only known mammalian enzyme to cleave heparan sulfate (HS), thereby promoting the abovementioned release of LPL from the cardiomyocyte HSPG. In diabetes, it has been suggested that changes in how the heart generates energy are responsible for the development of diabetic cardiomyopathy (DCM). Following moderate diabetes, with the reduction in glucose utilization, the heart increases its LPL activity at the vascular lumen due to an increase in Hpa action. Although this adaptation might be beneficial to compensate for the underutilization of glucose by the heart, it is toxic over the long term, as harmful lipid metabolite accumulation, along with augmented FA oxidation and thus oxidative stress, leads to cell death. This coincides with the loss of a cardioprotective growth factor—namely, vascular endothelial growth factor B (VEGFB). This review discusses interconnections between Hpa, LPL, and VEGFB and their potential implications in DCM. Given that mechanism-based therapeutic care for DCM is unavailable, understanding the pathology of this cardiomyopathy, along with the contribution of LPL, will help us advance its clinical management.

Keywords： Cardiac metabolism Lipoprotein lipase Heparanase Vascular endothelial growth factor Diabetic cardiomyopathy

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Title Author Date Type Operation

Domain knowledge enhanced deep learning for electrocardiogram arrhythmia classification

Jie SUN,sunjie@nbut.edu.cn

Journal Article

Integrated management of cardiac failure: the cardiac failure clinic

Daniel LOISANCE

Journal Article

Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in

Journal Article

Association of cardiac disease with the risk of post-lung transplantation mortality in Chinese recipients

Journal Article

Management of mantle cell leukemia with cardiac involvement leading to cardiogenic shock

Muhammad Furqan,Yamei Chen,Akintunde Akinleye,Judy Sarungbam,Alan Gass,Karen Seiter,Delong Liu

Journal Article

Effects of RNA interference targeting angiotensin 1a receptor on blood pressure and cardiac hypertrophy

ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen

Journal Article

Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis

Wei Gong,Mengwen Yan,Junxiong Chen,Sandip Chaugai,Chen Chen,Daowen Wang

Journal Article

Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling

Samuel Chege Gitau,Xuelian Li,Dandan Zhao,Zhenfeng Guo,Haihai Liang,Ming Qian,Lifang Lv,Tianshi Li,Bozhi Xu,Zhiguo Wang,Yong Zhang,Chaoqian Xu,Yanjie Lu,Zhiming Du,Hongli Shan,Baofeng Yang

Journal Article

PAK1 is a novel cardiac protective signaling molecule

Yunbo Ke,Xin Wang,Xu Yu Jin,R. John Solaro,Ming Lei

Journal Article

Right coronary occlusion following transcatheter aortic valve implantation: two case reports

Gang Zhang,Jun Luo,Guo Chen

Journal Article

Cardiac Remote Conditioning and Clinical Relevance: All Together Now!

Kristin Luther,Yang Song,Yang Wang,Xiaoping Ren,W. Keith Jones

Journal Article

Familial amyloid cardiomyopathy masquerading as chronic Guillain-Barre syndrome: things are not always what they seem

Die Hu, Ling Liu, Shuguang Yuan, Yuhong Yi, Daoquan Peng